{"entity":{"id":"nct06850090","kind":"trial","name":"Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial","aka":[],"tldr":"A phase 3 trial of trifluridine/tipiracil and capecitabine in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.","summary":"Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial is a phase 3, randomised interventional study registered as NCT06850090 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 210 participants, started 2025-07-30 and due to reach its primary completion in 2027-06. Interventions recorded: TAS-102; Capecitabine. Conditions listed: Rectal Cancer; Rectal Cancer Patients. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: \"Histologically confirmed rectal adenocarcinoma with the following conditions:\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06850090","url":"https://clinicaltrials.gov/study/NCT06850090"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt"],"targets":[],"drugs":["trifluridine-tipiracil","capecitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06850090","phase":"3","setting":"Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial","sponsor":"Shandong Cancer Hospital and Institute","enrolled":210,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06850090/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"trifluridine-tipiracil","kind":"drug","name":"Trifluridine/tipiracil","route":"/drugs/trifluridine-tipiracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}