{"entity":{"id":"nct06857773","kind":"trial","name":"Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy","aka":["PUMP-IT RCT"],"tldr":"A phase 3 trial in colorectal cancer, run by The Netherlands Cancer Institute, now recruiting.","summary":"Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion Pump Therapy With Systemic Therapy is a phase 3, randomised interventional study registered as NCT06857773 by The Netherlands Cancer Institute, with a registry enrolment figure of 306 participants, started 2024-11-21 and due to reach its primary completion in 2030-01. Interventions recorded: Intra arterial infusion Floxuridine (FUDR) combined with systemic therapy; Hepatic arterial infusion pump (HAIP); Systemic therapy (standard of care). Conditions listed: Colorectal Neoplasms; Floxuridine; Liver Metastases; Vascular Access Device. Primary outcome: Overall survival. Colorectal eligibility wording from the registry: \"* Histologically confirmed colorectal adenocarcinoma\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06857773","url":"https://clinicaltrials.gov/study/NCT06857773"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06857773","phase":"3","setting":"Hepatic Arterial Infusion PUMP Chemotherapy Combined With Systemic Therapy Versus Systemic Therapy Alone as Induction Therapy for Initially Unresectable Colorectal Liver Metastases: a Randomised Controlled Trial","sponsor":"The Netherlands Cancer Institute","enrolled":306,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06857773/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}