{"entity":{"id":"nct06879717","kind":"trial","name":"A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients","aka":[],"tldr":"A phase 1/2 trial of Dostarlimab, Docetaxel in non-small-cell lung cancer and small-cell lung cancer, run by iOnctura, active and no longer recruiting.","summary":"A Study of Roginolisib (IOA-244) in Combination With Dostarlimab With or Without Docetaxel in Metastatic Non Small-cell Lung Cancer (NSCLC) Patients is a phase 1/2 interventional study registered as NCT06879717 by iOnctura, with 45 participants planned, started 2025-04-22 and due to reach its primary completion in 2027-01. Interventions recorded: roginolisib, Dostarlimab, Docetaxel. Conditions listed: Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Advanced Non Squamous NSCLC. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06879717","url":"https://clinicaltrials.gov/study/NCT06879717"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["dostarlimab","docetaxel"],"companies":["ionctura"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT06879717","phase":"1/2","setting":"A Phase I/IIa Study of Roginolisib in Combination With Dostarlimab With or Without Docetaxel in Patients With Advanced Non-squamous NSCLC Who Have Progressed on Standard of Care Immune Checkpoint Therapy and Platinum Doublet Chemotherapy or Standard Immunotherapy Without Chemotherapy (PULMO-1)","sponsor":"iOnctura","enrolled":45,"outcomes":[]},"route":"/trials/nct06879717/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"docetaxel","kind":"drug","name":"Docetaxel","route":"/drugs/docetaxel/"},{"id":"dostarlimab","kind":"drug","name":"Dostarlimab","route":"/drugs/dostarlimab/"},{"id":"roginolisib","kind":"drug","name":"Roginolisib","route":"/drugs/roginolisib/"}],"company":[{"id":"ionctura","kind":"company","name":"iOnctura","route":"/companies/ionctura/"}]}}