{"entity":{"id":"nct06885645","kind":"trial","name":"KH815 first-in-human study","aka":[],"tldr":"A planned early study of KH815 in people with advanced solid tumors. The registry still lists it as not yet recruiting, with no results posted.","summary":"NCT06885645 is a first-in-human dose-escalation study of the dual-payload TROP2 ADC KH815. The ClinicalTrials.gov record last posted 3 April 2025 lists NOT_YET_RECRUITING, estimated enrollment of 30, an estimated start on 30 April 2025 and estimated primary completion on 30 June 2027. These dates remain estimates when checked 6 October 2026; no results or study locations are posted. The protocol excludes a history of interstitial lung disease/pneumonia or screening imaging on which it cannot be ruled out. Registered status does not confirm current availability or individual eligibility.","status":"planned","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT06885645","url":"https://clinicaltrials.gov/study/NCT06885645"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["adc","dual-payload-adc"],"targets":["trop2"],"drugs":["kh815"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06885645","phase":"1","setting":"Advanced or unresectable solid tumors after failure of, difficulty with, or unsuitability for standard therapies; measurable disease and ECOG performance status 0 or 1 required.","sponsor":"Chengdu Kanghong Biotech Co., Ltd.","started":"2025-04-30","startedType":"estimated","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06885645/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"dual-payload-adc","kind":"technology","name":"Dual-payload ADC","route":"/technologies/dual-payload-adc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"drug":[{"id":"kh815","kind":"drug","name":"KH815","route":"/drugs/kh815/"}]}}