{"entity":{"id":"nct06890624","kind":"trial","name":"mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer","aka":["OPTICAL-3"],"tldr":"A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.","summary":"mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer is a phase 2, randomised interventional study registered as NCT06890624 by Sun Yat-sen University, with a registry enrolment figure of 138 participants, started 2026-10-01 and due to reach its primary completion in 2029-10-01. Interventions recorded: cmFOLFOXIRI plus PD-1 inhibitor; mFOLFOX6. Conditions listed: Colon Cancer (Stage II &Amp;Amp; III). Primary outcome: Pathologic complete response rate. Colorectal eligibility wording from the registry: \"Histological or cytological documentation of adenocarcinoma of the colon (≥ 12 cm from the anal verge)\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06890624","url":"https://clinicaltrials.gov/study/NCT06890624"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["folfox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06890624","phase":"2","setting":"Chinese Modified FOLFOXIRI Combined With PD-1 Inhibitor Versus mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer (cT4/N2): A Multicenter, Randomized, Controlled, Phase II Trial","sponsor":"Sun Yat-sen University","enrolled":138,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06890624/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}