{"entity":{"id":"nct06899477","kind":"trial","name":"Pre-Operative Treatment in REseCTable COlon CanceR","aka":[],"tldr":"A phase 3 trial of FOLFOXIRI, fOLFOX (5-FU, leucovorin, oxaliplatin) and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Dominik Paul Modest, not yet recruiting.","summary":"Pre-Operative Treatment in REseCTable COlon CanceR is a phase 3, randomised interventional study registered as NCT06899477 by Dominik Paul Modest, with a registry enrolment figure of 714 participants, started 2025-04 and due to reach its primary completion in 2033-04. Interventions recorded: mFOLFOXIRI; mFOLFOX-6; CAPOX. Conditions listed: Colo-rectal Cancer; Colon Cancer; Colon Carcinoma. Primary outcome: Disease-free survival (DFS). Colorectal eligibility wording from the registry: \"Histologically confirmed adenocarcinoma of the colon or upper rectum\". Sites: Germany. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06899477","url":"https://clinicaltrials.gov/study/NCT06899477"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum","topoisomerase-inhibitors"],"targets":[],"drugs":["folfoxiri","folfox","capox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06899477","phase":"3","setting":"Pre-Operative Treatment in REseCTable COlon CanceR (PROTECTOR/FIRE-10; AIO-KRK-0620; IAG-VO-0323) Prospective, Randomized, Open, Multicenter Phase III Trial to Investigate the Efficacy Preoperative Systemic Therapy in Advanced Colon Cancer","sponsor":"Dominik Paul Modest","enrolled":714,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06899477/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"},{"id":"folfoxiri","kind":"drug","name":"FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)","route":"/drugs/folfoxiri/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}