{"entity":{"id":"nct06903858","kind":"trial","name":"Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer","aka":["PICC-3"],"tldr":"A phase 2 trial of toripalimab and celecoxib in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT06903858 by Sun Yat-sen University, with a registry enrolment figure of 105 participants, started 2025-06-01 and due to reach its primary completion in 2028-04-01. Interventions recorded: Toripalimab plus celecoxib; Non-operative management; Curative-intent surgery. Conditions listed: Colorectal Cancer; Microsatellite Instability High; Mismatch Repair Deficiency. Primary outcome: Event-free survival (EFS). Colorectal eligibility wording from the registry: \"Histologically confirmed colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06903858","url":"https://clinicaltrials.gov/study/NCT06903858"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["toripalimab","celecoxib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06903858","phase":"2","setting":"Toripalimab Plus Celecoxib With Response-adapted Non-operative Management for Mismatch Repair-deficient or Microsatellite Instability-high Locally Advanced Colorectal Cancer (PICC-3): a Multicenter, Single-arm, Phase 2 Trial","sponsor":"Sun Yat-sen University","enrolled":105,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06903858/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"celecoxib","kind":"drug","name":"Celecoxib","route":"/drugs/celecoxib/"},{"id":"toripalimab","kind":"drug","name":"Toripalimab","route":"/drugs/toripalimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}