{"entity":{"id":"nct06907342","kind":"trial","name":"Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)","aka":["COSENSE-1"],"tldr":"A phase 2 trial in colorectal cancer, run by St. Olavs Hospital, now recruiting.","summary":"Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1) is a phase 2, interventional study registered as NCT06907342 by St. Olavs Hospital, with a registry enrolment figure of 148 participants, started 2025-05-23 and due to reach its primary completion in 2027-12. Interventions recorded: FOLFOX or FOLFIRI. Conditions listed: Tumor, Colorectal; Organoids; Tumoroid; Metastatic Colorectal Cancer; Core Needle Biopsy; First-line Treatment. Primary outcome: Test the feasibility of using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens for patients with metastatic colorectal cancer.; Test the feasibility of using a functional precision medicine platform to select oxaliplatin-based versus . Colorectal eligibility wording from the registry: \"Histologically confirmed pMMR/MSS adenocarcinoma originating from the colon or rectum\". Sites: Norway. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06907342","url":"https://clinicaltrials.gov/study/NCT06907342"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06907342","phase":"2","setting":"COSENSE-1: A Feasibility Study for Using a Functional Precision Medicine Platform to Select Oxaliplatin-based Versus Irinotecan-based Chemotherapy Regimens for Patients With Metastatic Colorectal Cancer","sponsor":"St. Olavs Hospital","enrolled":148,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06907342/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}