{"entity":{"id":"nct06919510","kind":"trial","name":"A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 2 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.","summary":"A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT06919510 by Sun Yat-sen University, with a registry enrolment figure of 90 participants, started 2025-04-01 and due to reach its primary completion in 2026-06-01. Interventions recorded: lvonescimab; CAPOX (oxaliplatin/capecitabine); radiotherapy; Surgery or watch&wait. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Adverse events; Complete response rate; Clinical complete response rate. Colorectal eligibility wording from the registry: \"Histologically proven rectal adenocarcinoma;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06919510","url":"https://clinicaltrials.gov/study/NCT06919510"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt","platinum"],"targets":[],"drugs":["capox"],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06919510","phase":"2","setting":"A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Lvonescimab and Chemotherapy Versus Neoadjuvant Short-course Radiotherapy Followed by Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer","sponsor":"Sun Yat-sen University","enrolled":90,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06919510/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}