{"entity":{"id":"nct06922591","kind":"trial","name":"Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients","aka":[],"tldr":"A phase 1/2 trial of TNG462, Zoldonrasib, Daraxonrasib in pancreatic ductal adenocarcinoma, run by Tango Therapeutics, Inc., now recruiting.","summary":"Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients is a phase 1/2 interventional study registered as NCT06922591 by Tango Therapeutics, Inc., with 183 participants planned, started 2025-05-31 and due to reach its primary completion in 2027-06. Interventions recorded: TNG462, RMC-9805, RMC-6236, mFOLFIRINOX, gemcitabine/nab-paclitaxel. Conditions listed: PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, NSCLC, RAS Mutation. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06922591","url":"https://clinicaltrials.gov/study/NCT06922591"}],"tags":["ctgov-ingest"],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":["tng462","zoldonrasib","daraxonrasib","folfirinox","gemcitabine","paclitaxel"],"companies":["tango-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT06922591","phase":"1/2","setting":"A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability & Antitumor Activity of TNG462 in Combination With Other Agents in Patients With Pancreatic Cancer With MTAP Loss and Pancreatic or Non-Small Cell Lung Cancer With MTAP Loss & RAS Mutation","sponsor":"Tango Therapeutics, Inc.","enrolled":183,"outcomes":[]},"route":"/trials/nct06922591/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"daraxonrasib","kind":"drug","name":"Daraxonrasib","route":"/drugs/daraxonrasib/"},{"id":"folfirinox","kind":"drug","name":"FOLFIRINOX / mFOLFIRINOX","route":"/drugs/folfirinox/"},{"id":"gemcitabine","kind":"drug","name":"Gemcitabine","route":"/drugs/gemcitabine/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"},{"id":"tng462","kind":"drug","name":"TNG462","route":"/drugs/tng462/"},{"id":"zoldonrasib","kind":"drug","name":"Zoldonrasib","route":"/drugs/zoldonrasib/"}],"company":[{"id":"tango-therapeutics","kind":"company","name":"Tango Therapeutics","route":"/companies/tango-therapeutics/"}]}}