{"entity":{"id":"nct06923345","kind":"trial","name":"Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I) is a phase 2, randomised interventional study registered as NCT06923345 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 80 participants, started 2025-03-31 and due to reach its primary completion in 2027-12-31. Interventions recorded: Reduced CTV; Conventional CTV. Conditions listed: Rectal Cancer; Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiotherapy. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06923345","url":"https://clinicaltrials.gov/study/NCT06923345"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06923345","phase":"2","setting":"Modified Long-Course Radiotherapy (Reduced vs. Conventional CTV), Sequential Chemotherapy and PD-1 Inhibitor in Locally Advanced, MSS, Mid-Low Rectal Cancer: An Open-Label, Two-Arm, Randomized, Prospective Phase II Clinical Trial (MODIFI-RC-I)","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":80,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06923345/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}