{"entity":{"id":"nct06940388","kind":"trial","name":"Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.","aka":["TOTAL"],"tldr":"A phase 2 trial of tislelizumab in colorectal cancer, run by brenner baruch, now recruiting.","summary":"Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. is a phase 2, randomised interventional study registered as NCT06940388 by brenner baruch, with a registry enrolment figure of 134 participants, started 2025-07-23 and due to reach its primary completion in 2029-08. Interventions recorded: Tislelizumab; Total neoadjuvant therapy (TNT). Conditions listed: Locally Advanced Rectal Cancer (LARC). Primary outcome: 3-year total mesorectal excision (TME) free survival rates. Colorectal eligibility wording from the registry: \"* No prior chemotherapy, immunotherapy, radiotherapy or surgery for rectal cancer\". Sites: Germany, Israel. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06940388","url":"https://clinicaltrials.gov/study/NCT06940388"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["tislelizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06940388","phase":"2","setting":"Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer: An Open-label Randomized Controlled Phase II Study (The TOTAL Trial)","sponsor":"brenner baruch","enrolled":134,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06940388/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"tislelizumab","kind":"drug","name":"Tislelizumab","route":"/drugs/tislelizumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}