{"entity":{"id":"nct06946420","kind":"trial","name":"SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy","aka":["SENECA"],"tldr":"A phase 3 trial in pancreatic cancer, run by Fondazione Policlinico Universitario Agostino Gemelli IRCCS, active but no longer recruiting.","summary":"SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy is a phase 3, randomised interventional study registered as NCT06946420 by Fondazione Policlinico Universitario Agostino Gemelli IRCCS, with a registry enrolment figure of 108 participants, started 2025-01-10 and due to reach its primary completion in 2030-01-10. Interventions recorded: SBRT or RT on primary pancreatic and/or metastatic distant lesions before chemotherapy; Standard systemic therapy (chemotherapy) without RT/SBRT. Conditions listed: Radiation Therapy; SBRT; Pancreatic Cancer Metastatic. Primary outcome: Absence of symtomps. Pancreatic eligibility wording from the registry: \"* Patients diagnosed with pancreatic cancer, metastatic, candidate for first-line treatment standard systemic; either newly diagnosed in metastatic stage or first progression to metastasis\". Sites: Italy. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06946420","url":"https://clinicaltrials.gov/study/NCT06946420"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06946420","phase":"3","setting":"SENECA: First Line metaStatic pancrEatic caNcer Primary and Distant (if Oligometastatic) lEsion direCted rAdiotherapy, a Phase III Randomized Multicentric Trial","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","enrolled":108,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06946420/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}