{"entity":{"id":"nct06957379","kind":"trial","name":"Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Who Have Failed Standard Therapy","aka":[],"tldr":"A phase 2 trial of Exemestane and Fulvestrant in advanced solid tumours, run by CSPC ZhongQi Pharmaceutical Technology Co., Ltd., active and no longer recruiting.","summary":"Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Who Have Failed Standard Therapy is a phase 2 interventional study registered as NCT06957379 by CSPC ZhongQi Pharmaceutical Technology Co., Ltd., with 78 participants enrolled, started 2024-02-29 and due to reach its primary completion in 2025-06. Interventions recorded: Letrozole, Anastrozole, Exemestane, Fulvestrant and Sirolimus for Injection (Albumin-bound).","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06957379","url":"https://clinicaltrials.gov/study/NCT06957379"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["exemestane","fulvestrant"],"companies":["cspc"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT06957379","phase":"2","setting":"A Phase II Clinical Trial of the Safety and Efficacy of Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for the Treatment of HR-positive, HER2-negative Patients With Advanced Breast Cancer Who Have Failed Standard Therapy","sponsor":"CSPC ZhongQi Pharmaceutical Technology Co., Ltd.","enrolled":78,"outcomes":[]},"route":"/trials/nct06957379/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"exemestane","kind":"drug","name":"Exemestane","route":"/drugs/exemestane/"},{"id":"fulvestrant","kind":"drug","name":"Fulvestrant","route":"/drugs/fulvestrant/"}],"company":[{"id":"cspc","kind":"company","name":"CSPC Pharmaceutical Group","route":"/companies/cspc/"}]}}