{"entity":{"id":"nct06958432","kind":"trial","name":"Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)","aka":[],"tldr":"A phase 2/3 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II) is a phase 2/3, randomised interventional study registered as NCT06958432 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 430 participants, started 2025-05-01 and due to reach its primary completion in 2030-12-31. Interventions recorded: Node-Sparing Radiotherapy plus Chemotherapy and PD-1 inhibitor; Conventional Radiotherapy plus Chemotherapy and PD-1 inhibitor. Conditions listed: Rectal Cancer; Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiotherapy. Primary outcome: Complete response (CR) rate; Event-Free Survival (EFS). Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06958432","url":"https://clinicaltrials.gov/study/NCT06958432"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06958432","phase":"2/3","setting":"Node-Sparing Short-Course Radiotherapy Plus Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer: An Open-Label, Randomized, Prospective Phase II/III Trial (MODIFI-RC-II)","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":430,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06958432/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}