{"entity":{"id":"nct06972498","kind":"trial","name":"A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by The Fourth Affiliated Hospital of Zhejiang University School of Medicine, not yet recruiting.","summary":"A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets is a phase 2, interventional study registered as NCT06972498 by The Fourth Affiliated Hospital of Zhejiang University School of Medicine, with a registry enrolment figure of 35 participants, started 2025-07-01 and due to reach its primary completion in 2027-12-30. Interventions recorded: Patients will receive ivosimab combined with the XELOX/FOLFOX regimen, followed by radical surgery 4-6 weeks after the last dose; adjuvant chemotherapy will continue for 3 months postoperatively.. Conditions listed: Colorectal Cancer With Liver Metastasis. Primary outcome: ORR. Colorectal eligibility wording from the registry: \"Patients with pathologically or cytologically confirmed colorectal adenocarcinoma liver metastasis, and immunohistochemistry or genetic testing confirms pMMR/MSS\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06972498","url":"https://clinicaltrials.gov/study/NCT06972498"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06972498","phase":"2","setting":"A Prospective, Single-Arm, Multicenter Clinical Study on the Efficacy and Safety of Ivosimab Combined With Chemotherapy as Neoadjuvant Therapy in Patients With Resectable pMMR/MSS Colorectal Cancer Liver Metastases","sponsor":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","enrolled":35,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06972498/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}