{"entity":{"id":"nct06978400","kind":"trial","name":"A Study of Dabrafenib Plus Cetuximab/Panitumumab With FOLFOX in the First Line of Therapy in People With Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Blokhin's Russian Cancer Research Center, now recruiting.","summary":"A Study of Dabrafenib Plus Cetuximab/Panitumumab With FOLFOX in the First Line of Therapy in People With Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06978400 by Blokhin's Russian Cancer Research Center, with a registry enrolment figure of 64 participants, started 2025-03-01 and due to reach its primary completion in 2027-11-10. Interventions recorded: mFOLFOX6 + dabrafenib and cetuximab or panitumumab in the first line of therapy. Conditions listed: Neoplasms. Primary outcome: Objective Response Rate. Colorectal eligibility wording from the registry: \"* Histologically confirmed colorectal adenocarcinoma that contains MSS and BRAF V600E mutation\". Sites: Russia. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06978400","url":"https://clinicaltrials.gov/study/NCT06978400"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","braf-v600e-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06978400","phase":"2","setting":"Non-randomised, Multicentre, Prospective, Single-arm, Phase II Study of the Efficacy and Toxicity of a Combination of FOLFOX With Dabrafenib and Cetuximab/Panitumumab in the First Line of Therapy of Patients With Metastatic BRAF V600E- Mutated MSS Colorectal Cancer","sponsor":"Blokhin's Russian Cancer Research Center","enrolled":64,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06978400/","neighbours":{"cancer":[{"id":"braf-v600e-colorectal","kind":"cancer","name":"BRAF V600E-mutant colorectal cancer","route":"/cancers/braf-v600e-colorectal/"},{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}