{"entity":{"id":"nct06991465","kind":"trial","name":"Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)","aka":["Hypo-OPRA"],"tldr":"A phase 2 trial of capecitabine in colorectal cancer, run by Neil Kopek, now recruiting.","summary":"Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA) is a phase 2, interventional study registered as NCT06991465 by Neil Kopek, with a registry enrolment figure of 35 participants, started 2023-08-16 and due to reach its primary completion in 2027-09. Interventions recorded: Radiation Therapy; FOLFOX regimen; Capecitabine. Conditions listed: Colorectal Carcinoma. Primary outcome: Feasibility of Hypo-fractionated Approach in 5 fractions for a dose of 35Gy. Colorectal eligibility wording from the registry: \"* Histologically confirmed invasive adenocarcinoma of the rectum\". Sites: Canada. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06991465","url":"https://clinicaltrials.gov/study/NCT06991465"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt"],"targets":[],"drugs":["capecitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06991465","phase":"2","setting":"Organ Preservation in Rectal Adenocarcinoma Using Hypofractionated Pelvic Radiotherapy (Hypo-OPRA): A Phase II Clinical Trial","sponsor":"Neil Kopek","enrolled":35,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06991465/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}