{"entity":{"id":"nct06998758","kind":"trial","name":"Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Locally Advanced CRC","aka":["MATRIX"],"tldr":"A phase 3 trial of progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD) in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Locally Advanced CRC is a phase 3, randomised interventional study registered as NCT06998758 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 60 participants, started 2025-11-11 and due to reach its primary completion in 2027-05-10. Interventions recorded: Megestrol Acetate. Conditions listed: Neoadjuvant Chemotherapy; Weight Loss. Primary outcome: Incidence of weight loss. Colorectal eligibility wording from the registry: \"* Histologically confirmed colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06998758","url":"https://clinicaltrials.gov/study/NCT06998758"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["megestrol-progestins"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06998758","phase":"3","setting":"Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Patients With Locally Advanced Colorectal Cancer: A Multicenter Randomized Controlled Clinical Trial","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06998758/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"megestrol-progestins","kind":"drug","name":"Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD)","route":"/drugs/megestrol-progestins/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}