{"entity":{"id":"nct07006727","kind":"trial","name":"Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors","aka":[],"tldr":"A phase 1 trial of [225Ac]Ac-ETN029 run by Novartis Pharmaceuticals, now recruiting.","summary":"Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors is a phase 1 interventional study registered as NCT07006727 by Novartis Pharmaceuticals, with 116 participants planned, started 2025-10-16. Conditions recorded: Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung, Neuroendocrine Prostate Cancer, Gastroenteropancreatic Neuroendocrine Carcinoma, Non-prostate Extrapulmonary Neuroendocrine Carcinoma, Cervical Neuroendocrine Carcinoma, Thymic Neuroendocrine Carcinoma, Genitourinary Neuroendocrine Carcinoma, Unknown Primary Neuroendocrine Carcinomas, Merkel Cell Carcinoma and Medullary Thyroid Carcinoma. Interventions recorded: 225Ac-ETN029 and 111In-ETN029.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07006727","url":"https://clinicaltrials.gov/study/NCT07006727"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["sclc","lung-lcnec","prostate","extrapulmonary-nec","cervical","neuroendocrine","merkel-cell-carcinoma","medullary-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["etn029"],"companies":["mariana-oncology","novartis"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07006727","phase":"1","setting":"A Phase I, Open-label, Multi-center Study to Evaluate the Safety, Tolerability, Dosimetry, and Preliminary Activity of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors","sponsor":"Novartis Pharmaceuticals","enrolled":116,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07006727/","neighbours":{"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"extrapulmonary-nec","kind":"cancer","name":"Extrapulmonary neuroendocrine carcinoma","route":"/cancers/extrapulmonary-nec/"},{"id":"lung-lcnec","kind":"cancer","name":"Large cell neuroendocrine carcinoma of the lung","route":"/cancers/lung-lcnec/"},{"id":"medullary-thyroid-cancer","kind":"cancer","name":"Medullary thyroid cancer","route":"/cancers/medullary-thyroid-cancer/"},{"id":"merkel-cell-carcinoma","kind":"cancer","name":"Merkel cell carcinoma","route":"/cancers/merkel-cell-carcinoma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"etn029","kind":"drug","name":"[225Ac]Ac-ETN029","route":"/drugs/etn029/"}],"company":[{"id":"mariana-oncology","kind":"company","name":"Mariana Oncology","route":"/companies/mariana-oncology/"},{"id":"novartis","kind":"company","name":"Novartis","route":"/companies/novartis/"}]}}