{"entity":{"id":"nct07020221","kind":"trial","name":"A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of VS-7375, Cetuximab, Carboplatin in pancreatic ductal adenocarcinoma and non-small-cell lung cancer, run by Verastem, Inc., now recruiting.","summary":"A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors is a phase 1/2 interventional study registered as NCT07020221 by Verastem, Inc., with 295 participants planned, started 2025-06-24 and due to reach its primary completion in 2028-12. Interventions recorded: VS-7375, Cetuximab, Carboplatin + Pemetrexed + Pembrolizumab, Gemcitabine, Gemcitabine + Nab-paclitaxel. Conditions listed: Pancreatic Ductal Adenocarcinoma, Non Small Cell Lung Cancer, Colorectal Cancer, Solid Tumor, Adult. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07020221","url":"https://clinicaltrials.gov/study/NCT07020221"}],"tags":["ctgov-ingest"],"related":[],"cancers":["pancreatic","nsclc","sclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["vs-7375","cetuximab","carboplatin","pemetrexed","pembrolizumab","gemcitabine"],"companies":["verastem"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT07020221","phase":"1/2","setting":"A Phase 1/2, Open-label Study of VS-7375, a KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and in Combination, in Patients With Advanced KRAS G12D-Mutated Solid Tumors","sponsor":"Verastem, Inc.","enrolled":295,"outcomes":[]},"route":"/trials/nct07020221/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"gemcitabine","kind":"drug","name":"Gemcitabine","route":"/drugs/gemcitabine/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"},{"id":"pemetrexed","kind":"drug","name":"Pemetrexed","route":"/drugs/pemetrexed/"},{"id":"vs-7375","kind":"drug","name":"VS-7375","route":"/drugs/vs-7375/"}],"company":[{"id":"verastem","kind":"company","name":"Verastem Oncology","route":"/companies/verastem/"}]}}