{"entity":{"id":"nct07026422","kind":"trial","name":"Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT)","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.","summary":"Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT) is a phase 2, interventional study registered as NCT07026422 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 54 participants, started 2025-04-30 and due to reach its primary completion in 2026-11-30. Interventions recorded: Total neoadjuvant therapy integrating iparomlimab/tuvonralimab with chemoradiotherapy. Conditions listed: Rectal Malignant Neoplasms. Primary outcome: Overall complete response (CR) rate. Colorectal eligibility wording from the registry: \"Histologically confirmed pMMR/MSS rectal adenocarcinoma, defined by MRI as clinical stage II (T3-4, N-) or stage III (any T, N+)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07026422","url":"https://clinicaltrials.gov/study/NCT07026422"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07026422","phase":"2","setting":"Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT): A Single-arm, Exploratory, Phase II Trial","sponsor":"Shandong Cancer Hospital and Institute","enrolled":54,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07026422/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}