{"entity":{"id":"nct07042685","kind":"trial","name":"Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by The Methodist Hospital Research Institute, now recruiting.","summary":"Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT07042685 by The Methodist Hospital Research Institute, with a registry enrolment figure of 50 participants, started 2026-01-27 and due to reach its primary completion in 2028-12. Interventions recorded: Fruquintinib Combined With Chemotherapy. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Time to Progression of 5FU in combination with fruquintinib in first-line metastatic colorectal cancer patients. Colorectal eligibility wording from the registry: \"Histopathologically or cytologically confirmed locally advanced unresectable or metastatic colorectal cancer\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07042685","url":"https://clinicaltrials.gov/study/NCT07042685"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07042685","phase":"2","setting":"Phase II Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib as First Line in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer","sponsor":"The Methodist Hospital Research Institute","enrolled":50,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07042685/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}