{"entity":{"id":"nct07050043","kind":"trial","name":"Low Dose Nivolumab With Chemotherapy vs Standard Chemotherapy as First-Line Treatment in Advanced or Metastatic NSCLC","aka":["LEDANG"],"tldr":"A phase 3 trial in lung cancer, run by Dr Arvindran A/L Alaga, now recruiting.","summary":"Low Dose Nivolumab With Chemotherapy vs Standard Chemotherapy as First-Line Treatment in Advanced or Metastatic NSCLC is a phase 3, randomised interventional study registered as NCT07050043 by Dr Arvindran A/L Alaga, with a registry enrolment figure of 123 participants, started 2025-05-19 and due to reach its primary completion in 2030-12-31. Interventions recorded: Nivolumab 40mg; Cisplatin, Carboplatin, Pemetrexed, Gemcitabine, Paclitaxel, Docetaxel. Conditions listed: NSCLC (Non-small Cell Lung Carcinoma); First Line Therapy; Locally Advanced/Metastatic NSCLC. Primary outcome: Progression Free Survival (PFS). Lung eligibility wording from the registry: \"Histologically confirmed, treatment naïve, locally advanced, or metastatic (stage IIIB - IV (per AJCC version 8), squamous or non-squamous NSCLC with documented PD-L1 expression and is not eligible for definitive chemo-radiation curative therapy and surgery\". Sites: Malaysia. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07050043","url":"https://clinicaltrials.gov/study/NCT07050043"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07050043","phase":"3","setting":"A Phase III RCT Comparing Low Dose Immunotherapy (Nivolumab) Combined With Standard Chemotherapy vs Standard Chemotherapy as First-line Treatment in Patients With Locally Advanced or Metastatic NSCLC","sponsor":"Dr Arvindran A/L Alaga","enrolled":123,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07050043/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}