{"entity":{"id":"nct07057791","kind":"trial","name":"Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung Cancer","aka":["PrE0510"],"tldr":"A phase 2 trial in lung cancer, run by PrECOG, LLC., now recruiting.","summary":"Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung Cancer is a phase 2, randomised interventional study registered as NCT07057791 by PrECOG, LLC., with a registry enrolment figure of 60 participants, started 2026-03-30 and due to reach its primary completion in 2027-12. Interventions recorded: Ivonescimab 10 mg/kg; Ivonescimab 20 mg/kg. Conditions listed: Extensive Stage Lung Small Cell Cancer. Primary outcome: Optimal Dose of Ivonescimab in Combination with Carboplatin and Etoposide - Overall Response Rate (ORR); Optimal Dose of Ivonescimab in Combination with Carboplatin and Etoposide - Grade 3-5 Treatment-Related Toxicity Rate. Lung eligibility wording from the registry: \"* Patients must have pathologically confirmed Extensive Stage Small Cell Lung Cancer (ES-SCLC)\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07057791","url":"https://clinicaltrials.gov/study/NCT07057791"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["extensive-stage-sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["summit-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07057791","phase":"2","setting":"Phase II Dose Optimization Study of Platinum/Etoposide Plus Ivonescimab (CEI) as First-Line Treatment of Extensive-Stage Small Cell Lung Cancer","sponsor":"PrECOG, LLC.","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07057791/","neighbours":{"cancer":[{"id":"extensive-stage-sclc","kind":"cancer","name":"Extensive-stage small-cell lung cancer","route":"/cancers/extensive-stage-sclc/"}],"company":[{"id":"summit-therapeutics","kind":"company","name":"Summit Therapeutics","route":"/companies/summit-therapeutics/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}