{"entity":{"id":"nct07064018","kind":"trial","name":"Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies","aka":[],"tldr":"A phase 1/2 trial of pegfilgrastim and filgrastim (g-csf) in triple-negative breast cancer, run by University of California, Irvine, now recruiting.","summary":"Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies is a phase 1/2, interventional study registered as NCT07064018 by University of California, Irvine, with a registry enrolment figure of 67 participants, started 2025-04-30 and due to reach its primary completion in 2029-12-31. Interventions recorded: Spedox-6; Pegfilgrastim; Filgrastim. Conditions listed: Soft-tissue Sarcoma; Triple Negative Breast Cancer; Non-small Cell Lung Cancer; Cervical Cancer; Ovarian Cancer; KRAS Mutation-Related Tumors. Triple-negative eligibility wording from the registry: \"* Tumor types expected to express lower levels of FcRn relative to normal tissue including: STS, TNBC, cervical cancer, NSCLC, ovarian cancer, and KRAS mutated pancreatic ductal adenocarcinoma without requirement for testing FcRn level\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07064018","url":"https://clinicaltrials.gov/study/NCT07064018"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":["pegfilgrastim","filgrastim"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07064018","phase":"1/2","setting":"Phase Ib/IIa Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies","sponsor":"University of California, Irvine","enrolled":67,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07064018/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"drug":[{"id":"filgrastim","kind":"drug","name":"Filgrastim (G-CSF)","route":"/drugs/filgrastim/"},{"id":"pegfilgrastim","kind":"drug","name":"Pegfilgrastim","route":"/drugs/pegfilgrastim/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}