{"entity":{"id":"nct07066995","kind":"trial","name":"Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer","aka":["BAH2573-102"],"tldr":"A phase 1/2 trial of EB-MF-CAR-NK-01 in pancreatic cancer, run by Essen Biotech, now recruiting.","summary":"Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer is a phase 1/2, interventional study registered as NCT07066995 by Essen Biotech, with a registry enrolment figure of 60 participants, started 2025-04-29 and due to reach its primary completion in 2027-12-10. Interventions recorded: Mesothelin and Claudin 18.2 CAR-T cells. Conditions listed: Pancreatic Cancer; Pancreatic Carcinoma; Pancreatic Cancer Non-resectable; Pancreatic Cancer Stage IV. Primary outcome: Incidence and severity of dose-limiting toxicities (DLTs) following chemotherapy preparative regimen and infusion of CD19/BCMA chimeric antigen receptor (CAR) T cells. Pancreatic eligibility wording from the registry: \"* Histologically or cytologically confirmed pancreatic adenocarcinoma that is advanced (unresectable or metastatic)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07066995","url":"https://clinicaltrials.gov/study/NCT07066995"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac","metastatic-pdac"],"sections":[],"technologies":["car-t"],"targets":[],"drugs":["eb-mf-car-nk-01"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07066995","phase":"1/2","setting":"Dual-Target Chimeric Antigen Receptor (CAR) T-Cell Therapy Directed Against Mesothelin and Claudin 18.2 in Patients With Advanced or Metastatic Pancreatic Cancer","sponsor":"Essen Biotech","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07066995/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"},{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"drug":[{"id":"eb-mf-car-nk-01","kind":"drug","name":"EB-MF-CAR-NK-01","route":"/drugs/eb-mf-car-nk-01/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}