{"entity":{"id":"nct07074106","kind":"trial","name":"TIL-Driven De-escalated Chemotherapy in Stage I-II TNBC","aka":["DespaTIL"],"tldr":"A phase 2 trial of carboplatin in triple-negative breast cancer, run by D'Or Institute for Research and Education, now recruiting.","summary":"TIL-Driven De-escalated Chemotherapy in Stage I-II TNBC is a phase 2, interventional study registered as NCT07074106 by D'Or Institute for Research and Education, with a registry enrolment figure of 40 participants, started 2025-10-31 and due to reach its primary completion in 2027-07-01. Interventions recorded: Carboplatin and a Taxane. Conditions listed: Breast Cancer. Sites: Brazil. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07074106","url":"https://clinicaltrials.gov/study/NCT07074106"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-early"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["carboplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07074106","phase":"2","setting":"DespaTIL Study: A Phase II Trial of De-escalated Neoadjuvant Chemotherapy for Early-Stage Triple-Negative Breast Cancer Guided by Tumor-Infiltrating Lymphocytes (TILs) and Radiologic Response","sponsor":"D'Or Institute for Research and Education","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07074106/","neighbours":{"cancer":[{"id":"tnbc-early","kind":"cancer","name":"Early triple-negative breast cancer","route":"/cancers/tnbc-early/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}