{"entity":{"id":"nct07074353","kind":"trial","name":"Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer","aka":["CinClare-2"],"tldr":"A phase 3 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Zhejiang Cancer Hospital, not yet recruiting.","summary":"Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07074353 by Zhejiang Cancer Hospital, with a registry enrolment figure of 360 participants, started 2025-07-20 and due to reach its primary completion in 2028-04-01. Interventions recorded: NALIRI; LCRT; FOLFOX. Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: Complete Response rate（CR）. Colorectal eligibility wording from the registry: \"Histologically confirmed rectal adenocarcinoma;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07074353","url":"https://clinicaltrials.gov/study/NCT07074353"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","platinum"],"targets":[],"drugs":["folfox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07074353","phase":"3","setting":"A Randomized, Multicenter Clinical Study of Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer","sponsor":"Zhejiang Cancer Hospital","enrolled":360,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07074353/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}