{"entity":{"id":"nct07078604","kind":"trial","name":"A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer","aka":[],"tldr":"A phase 2 trial of sargramostim in triple-negative breast cancer, run by University of Washington, now recruiting.","summary":"A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer is a phase 2, interventional study registered as NCT07078604 by University of Washington, with a registry enrolment figure of 20 participants, started 2026-03-24 and due to reach its primary completion in 2027-04-30. Interventions recorded: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine; Chemotherapy; Computed Tomography; Sargramostim; Biospecimen Collection; Positron Emission Tomography (PET); Image Guided Biopsy. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma. Triple-negative eligibility wording from the registry: \"* Histologically confirmed triple-negative breast cancer\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07078604","url":"https://clinicaltrials.gov/study/NCT07078604"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":["sargramostim"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07078604","phase":"2","setting":"A Phase II Trial of the Immunogenicity of a DNA Plasmid-Based Vaccine (STEMVAC) Encoding Th1 Selective Epitopes From Five Antigens Associated With Breast Cancer Stem Cells (MDM2, YB1, SOX2, CDH3, CD105) in Patients With Metastatic Triple-Negative Breast Cancer","sponsor":"University of Washington","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07078604/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"drug":[{"id":"sargramostim","kind":"drug","name":"Sargramostim","route":"/drugs/sargramostim/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}