{"entity":{"id":"nct07124884","kind":"trial","name":"5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemother","aka":["COLOSOTO"],"tldr":"A phase 2 trial in colorectal cancer, run by Federation Francophone de Cancerologie Digestive, not yet recruiting.","summary":"5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab is a phase 2, interventional study registered as NCT07124884 by Federation Francophone de Cancerologie Digestive, with a registry enrolment figure of 300 participants, started 2025-08-31 and due to reach its primary completion in 2030-06-30. Interventions recorded: Administration of experimental treatment association (sotorasib, panitumumab 5FU). Conditions listed: Colorectal Carcinoma; KRAS G12C Mutation; Unresectable Colorectal Cancer. Primary outcome: Percentage of patient alive or without progression 8 months after inclusion.. Colorectal eligibility wording from the registry: \"* Histologically proven advanced-stage unresectable locally advanced or metastatic colorectal adenocarcinoma\". Sites: France, Germany, Italy, Spain. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07124884","url":"https://clinicaltrials.gov/study/NCT07124884"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","kras-g12c-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07124884","phase":"2","setting":"COLOSOTO: Single-arm Phase II Study Evaluating 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab","sponsor":"Federation Francophone de Cancerologie Digestive","enrolled":300,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07124884/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"kras-g12c-colorectal","kind":"cancer","name":"KRAS G12C-mutant colorectal cancer","route":"/cancers/kras-g12c-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}