{"entity":{"id":"nct07153055","kind":"trial","name":"Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer","aka":["LOTS"],"tldr":"A phase 1/2 trial of lurbinectedin and osimertinib in lung cancer, run by Misty Shields, now recruiting.","summary":"Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer is a phase 1/2, interventional study registered as NCT07153055 by Misty Shields, with a registry enrolment figure of 16 participants, started 2026-08 and due to reach its primary completion in 2029-04. Interventions recorded: Lurbinectedin; Osimertinib. Conditions listed: Small Cell Lung Cancer ( SCLC ); Transformed Small Cell Lung Cancer. Primary outcome: Grade 3 or dose-limiting toxicities. Lung eligibility wording from the registry: \"Must have a histologically or cytologically confirmed transformation to small cell lung carcinoma/cancer\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07153055","url":"https://clinicaltrials.gov/study/NCT07153055"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["sclc"],"sections":[],"technologies":["cytotoxic-chemotherapy","kinase-inhibitors"],"targets":[],"drugs":["lurbinectedin","osimertinib"],"companies":["jazz"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07153055","phase":"1/2","setting":"Phase I/II Trial of Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer","sponsor":"Misty Shields","enrolled":16,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07153055/","neighbours":{"cancer":[{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"lurbinectedin","kind":"drug","name":"Lurbinectedin","route":"/drugs/lurbinectedin/"},{"id":"osimertinib","kind":"drug","name":"Osimertinib","route":"/drugs/osimertinib/"}],"company":[{"id":"jazz","kind":"company","name":"Jazz Pharmaceuticals","route":"/companies/jazz/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}