{"entity":{"id":"nct07154368","kind":"trial","name":"JYP0322 Versus Platinum Based Doublet Chemotherapy in ROS1 Positive Patients Previously Treated With ROS1-TKIs.","aka":[],"tldr":"A phase 3 trial of pemetrexed in lung cancer, run by Guangzhou JOYO Pharma Co., Ltd, not yet recruiting.","summary":"JYP0322 Versus Platinum Based Doublet Chemotherapy in ROS1 Positive Patients Previously Treated With ROS1-TKIs. is a phase 3, randomised interventional study registered as NCT07154368 by Guangzhou JOYO Pharma Co., Ltd, with a registry enrolment figure of 207 participants, started 2025-09-23 and due to reach its primary completion in 2027-10-31. Interventions recorded: Pemetrexed injection; Cross-over to JYP0322; JYP0322 tablets. Conditions listed: Non Small Cell Lung Cancer. Primary outcome: Progression Free Survival (PFS) by BICR Assessment. Lung eligibility wording from the registry: \"* Subjects with histologically or cytologically documented NSCLC\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07154368","url":"https://clinicaltrials.gov/study/NCT07154368"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["ros1-positive-nsclc"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["pemetrexed"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07154368","phase":"3","setting":"A Randomized, Open-Label, Multicenter, Phase 3 Study Evaluating the Efficacy and Safety of JYP0322 Versus Platinum-Based Chemotherapy in ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer Patients Previously Treated With ROS1-TKI Therapy.","sponsor":"Guangzhou JOYO Pharma Co., Ltd","enrolled":207,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07154368/","neighbours":{"cancer":[{"id":"ros1-positive-nsclc","kind":"cancer","name":"ROS1-positive non-small-cell lung cancer","route":"/cancers/ros1-positive-nsclc/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"pemetrexed","kind":"drug","name":"Pemetrexed","route":"/drugs/pemetrexed/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}