{"entity":{"id":"nct07161115","kind":"trial","name":"Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer","aka":["REFIRT"],"tldr":"A phase 2 trial in colorectal cancer, run by Longhao Li, not yet recruiting.","summary":"Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07161115 by Longhao Li, with a registry enrolment figure of 60 participants, started 2025-09-19 and due to reach its primary completion in 2028-08-31. Interventions recorded: Reduced-field short-course radiotherapy; Immunotherapy combined with chemotherapy; Standard short-course radiotherapy; Standard long-course radiotherapy; Chemotherapy. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Two-year local control rate after rectal cancer surgery. Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07161115","url":"https://clinicaltrials.gov/study/NCT07161115"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07161115","phase":"2","setting":"A Phase II Study Evaluating the Efficacy and Safety of Neoadjuvant Therapy With MRI-Guided Involve-site Short-Course Radiotherapy Combined With Immunotherapy and Chemotherapy for Locally Advanced Rectal Cancer","sponsor":"Longhao Li","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07161115/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}