{"entity":{"id":"nct07176182","kind":"trial","name":"Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression is a phase 2, randomised interventional study registered as NCT07176182 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 236 participants, started 2026-03-20 and due to reach its primary completion in 2031-03-20. Interventions recorded: mFOLFOX regimen combined with Citrus Flavone Tablets (Alvenor) neoadjuvant treatment group; mFOLFOX regimen neoadjuvant therapy group. Conditions listed: Rectal Cancer Patients; Rectal Cancer Stage II; Rectal Cancer Stage III. Primary outcome: Tumor downstaging rate (to ypTNM stage 0-I). Colorectal eligibility wording from the registry: \"Histopathologically confirmed rectal adenocarcinoma; all other histologic subtypes are excluded\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07176182","url":"https://clinicaltrials.gov/study/NCT07176182"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07176182","phase":"2","setting":"mFOLFOX6 Combined With Citrus Flavonoid Tablets (Aimailang) as Neoadjuvant Therapy for Locally Advanced Rectal Cancer With High YWHAB Expression: A Prospective, Multi-center, Open-Label, Randomized Controlled Phase II Clinical Trial","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":236,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07176182/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}