{"entity":{"id":"nct07188025","kind":"trial","name":"ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer","aka":["REACT"],"tldr":"A phase 3 trial in colorectal cancer, run by Erasmus Medical Center, now recruiting.","summary":"ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer is a phase 3, randomised interventional study registered as NCT07188025 by Erasmus Medical Center, with a registry enrolment figure of 103 participants, started 2025-10-14 and due to reach its primary completion in 2030-10. Interventions recorded: Adjuvant chemotherapy. Conditions listed: Rectal Cancer. Primary outcome: Disease-free survival, intention-to-treat. Colorectal eligibility wording from the registry: \"* Histological confirmed rectal cancer; either treated with neoadjuvant (chemo)radiotherapy, and/or clinical/pathological T3/T4 and/or N+ in case no neoadjuvant therapy was administered\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07188025","url":"https://clinicaltrials.gov/study/NCT07188025"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07188025","phase":"3","setting":"Adjuvant Chemotherapy for Prevention of Recurrence in Patients With Detectable ctDNA After Surgery in High-Risk Rectal Cancer","sponsor":"Erasmus Medical Center","enrolled":103,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07188025/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}