{"entity":{"id":"nct07192068","kind":"trial","name":"Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.","aka":["AcSé HER2"],"tldr":"A phase 2 trial of zanidatamab in colorectal cancer, run by UNICANCER, now recruiting.","summary":"Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene. is a phase 2, interventional study registered as NCT07192068 by UNICANCER, with a registry enrolment figure of 105 participants, started 2025-10-30 and due to reach its primary completion in 2028-03-13. Interventions recorded: Zanidatamab. Conditions listed: Non-Small Cell Lung Cancer; Sarcoma; Head &Amp; Neck Cancer; Colorectal Carcinoma; Endometrial. Primary outcome: Confirmed Objective Response Rate (ORR) by investigator. Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed endometrial, colorectal, head \\& neck, non-small cell lung cancer (NSCLC), or sarcoma\". Sites: France. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07192068","url":"https://clinicaltrials.gov/study/NCT07192068"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","her2-amplified-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["zanidatamab"],"companies":["jazz","unicancer"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07192068","phase":"2","setting":"Widening Treatment Options Among Adult Patients With HER2-overexpressing or Mutant Solid Cancers.","sponsor":"UNICANCER","enrolled":105,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07192068/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"her2-amplified-colorectal","kind":"cancer","name":"HER2-amplified colorectal cancer","route":"/cancers/her2-amplified-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"zanidatamab","kind":"drug","name":"Zanidatamab","route":"/drugs/zanidatamab/"}],"company":[{"id":"jazz","kind":"company","name":"Jazz Pharmaceuticals","route":"/companies/jazz/"},{"id":"unicancer","kind":"company","name":"UNICANCER","route":"/companies/unicancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}