{"entity":{"id":"nct07214298","kind":"trial","name":"Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma","aka":[],"tldr":"A phase 1/2 trial of fluorouracil (5-FU), fOLFIRI (5-FU, leucovorin, irinotecan), leucovorin (folinic acid) and cAPOX (capecitabine, oxaliplatin) in pancreatic cancer, run by Roswell Park Cancer Institute, now recruiting.","summary":"Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma is a phase 1/2, interventional study registered as NCT07214298 by Roswell Park Cancer Institute, with a registry enrolment figure of 35 participants, started 2026-02-16 and due to reach its primary completion in 2028-02-16. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Computed Tomography; Fluorouracil; Irinotecan; Leucovorin Calcium; Magnetic Resonance Imaging; Oxaliplatin; Pegcetacoplan. Conditions listed: Metastatic Pancreatic Ductal Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Incidence of treatment-related adverse events (AE) (Phase I); Progression-free survival (Phase II). Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07214298","url":"https://clinicaltrials.gov/study/NCT07214298"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["fluorouracil","folfiri","leucovorin","capox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07214298","phase":"1/2","setting":"A Phase I/II Study of Complement Inhibition in Pancreatic Ductal Adenocarcinoma","sponsor":"Roswell Park Cancer Institute","enrolled":35,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07214298/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"fluorouracil","kind":"drug","name":"Fluorouracil (5-FU)","route":"/drugs/fluorouracil/"},{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"leucovorin","kind":"drug","name":"Leucovorin (folinic acid)","route":"/drugs/leucovorin/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}