{"entity":{"id":"nct07262619","kind":"trial","name":"EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Partic","aka":[],"tldr":"A phase 1/2 trial of Pembrolizumab in colorectal cancer and endometrial cancer, run by Eikon Therapeutics, now recruiting.","summary":"EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors is a phase 1/2 interventional study registered as NCT07262619 by Eikon Therapeutics, with 160 participants planned, started 2026-01-20 and due to reach its primary completion in 2029-03. Interventions recorded: EIK1005, pembrolizumab (KEYTRUDA® ). Conditions listed: Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors, MSI-H/dMMR Gastric Cancer, MSI-H/dMMR Colorectal Cancer. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07262619","url":"https://clinicaltrials.gov/study/NCT07262619"}],"tags":["ctgov-ingest"],"related":[],"cancers":["colorectal","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":["pembrolizumab"],"companies":["eikon-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT07262619","phase":"1/2","setting":"A Multicenter, Multi-Part, Phase 1/2 Study of EIK1005 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors, Including Checkpoint Inhibitor Naïve Participants With Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Tumors","sponsor":"Eikon Therapeutics","enrolled":160,"outcomes":[]},"route":"/trials/nct07262619/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}],"drug":[{"id":"eik1005","kind":"drug","name":"EIK1005","route":"/drugs/eik1005/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"company":[{"id":"eikon-therapeutics","kind":"company","name":"Eikon Therapeutics","route":"/companies/eikon-therapeutics/"}]}}