{"entity":{"id":"nct07277322","kind":"trial","name":"Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases","aka":[],"tldr":"A phase 1/2 trial of toripalimab in colorectal cancer, run by Dan Feng, now recruiting.","summary":"Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases is a phase 1/2, interventional study registered as NCT07277322 by Dan Feng, with a registry enrolment figure of 24 participants, started 2026-09-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: Dupilumab; Toripalimab. Conditions listed: Metastatic Colorectal Cancer; Liver Metastases. Primary outcome: Number of dose limiting toxicities (DLTs). Colorectal eligibility wording from the registry: \"* Has not undergone a hysterectomy or bilateral oophorectomy; or\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07277322","url":"https://clinicaltrials.gov/study/NCT07277322"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["toripalimab"],"companies":["coherus"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07277322","phase":"1/2","setting":"Master Protocol for A Phase 1b/2 Study of Neoadjuvant Immunotherapy in Microsatellite Stable (MSS) Colorectal Cancer (CRC) Subjects With Resectable Liver Metastases","sponsor":"Dan Feng","enrolled":24,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07277322/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"toripalimab","kind":"drug","name":"Toripalimab","route":"/drugs/toripalimab/"}],"company":[{"id":"coherus","kind":"company","name":"Coherus BioSciences","route":"/companies/coherus/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}