{"entity":{"id":"nct07279077","kind":"trial","name":"Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Ar","aka":["MODIFI-L"],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial is a phase 2, interventional study registered as NCT07279077 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 38 participants, started 2025-11-26 and due to reach its primary completion in 2030-11-25. Interventions recorded: Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor. Conditions listed: Colon Cancer; Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiation Therapy. Primary outcome: Pathological Complete Response(pCR) Rate. Colorectal eligibility wording from the registry: \"Histologically confirmed adenocarcinoma of the colon (without squamous or sarcomatoid components)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07279077","url":"https://clinicaltrials.gov/study/NCT07279077"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07279077","phase":"2","setting":"Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":38,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07279077/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}