{"entity":{"id":"nct07281716","kind":"trial","name":"Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC","aka":[],"tldr":"A phase 1/2 trial of toripalimab in colorectal cancer, run by Dan Feng, now recruiting.","summary":"Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC is a phase 1/2, interventional study registered as NCT07281716 by Dan Feng, with a registry enrolment figure of 24 participants, started 2025-12-01 and due to reach its primary completion in 2028-12-15. Interventions recorded: Nadunolimab; Toripalimab. Conditions listed: Metastatic Microsatellite Stable Colorectal Carcinoma. Primary outcome: Dose-Limiting Toxicities (DLTs); Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: o Has not undergone a hysterectomy or bilateral oophorectomy; or o Has not been naturally postmenopausal for at le\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07281716","url":"https://clinicaltrials.gov/study/NCT07281716"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["toripalimab"],"companies":["coherus"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07281716","phase":"1/2","setting":"A Phase 1b/2 Study of Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC)","sponsor":"Dan Feng","enrolled":24,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07281716/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"toripalimab","kind":"drug","name":"Toripalimab","route":"/drugs/toripalimab/"}],"company":[{"id":"coherus","kind":"company","name":"Coherus BioSciences","route":"/companies/coherus/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}