{"entity":{"id":"nct07284186","kind":"trial","name":"First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors","aka":[],"tldr":"A phase 1 trial of PLX-61639 run by Plexium, Inc., now recruiting.","summary":"First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors is a phase 1 interventional study registered as NCT07284186 by Plexium, Inc., with 155 participants planned, started 2025-12-01. Conditions recorded: Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Gastric Squamous Cell Carcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma, Metastatic Solid Tumor, Non-Small Cell Lung Carcinoma, Esophageal Adenocarcinoma, SMARCA4 Mutation, Gastroesophageal Junction Squamous Cell Carcinoma and Advanced Solid Tumor. Interventions recorded: PLX-61639.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07284186","url":"https://clinicaltrials.gov/study/NCT07284186"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["oesophageal-squamous-cell-carcinoma","gastric","metastatic-cancer","nsclc","oesophageal-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["plx-61639"],"companies":["plexium"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07284186","phase":"1","setting":"A Phase 1, First-in-Human Study of the SMARCA2 Degrader, PLX-61639, in Patients With SMARCA4-Mutated Locally Advanced or Metastatic Solid Tumors","sponsor":"Plexium, Inc.","enrolled":155,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07284186/","neighbours":{"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"oesophageal-squamous-cell-carcinoma","kind":"cancer","name":"Oesophageal squamous cell carcinoma","route":"/cancers/oesophageal-squamous-cell-carcinoma/"}],"drug":[{"id":"plx-61639","kind":"drug","name":"PLX-61639","route":"/drugs/plx-61639/"}],"company":[{"id":"plexium","kind":"company","name":"Plexium","route":"/companies/plexium/"}]}}