{"entity":{"id":"nct07287917","kind":"trial","name":"Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of Eflornithine, Fulvestrant, Capivasertib in melanoma and skin cancer, run by Aminex Therapeutics, Inc., now recruiting.","summary":"Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT07287917 by Aminex Therapeutics, Inc., with 92 participants planned, started 2026-01-26 and due to reach its primary completion in 2028-02-28. Interventions recorded: AMXT 1501 Dicaprate, DFMO, Fulvestrant, Capivasertib, Pembrolizumab. Conditions listed: Melanoma (Skin Cancer), HER2-low Hormone Receptor Positive Breast Cancer. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07287917","url":"https://clinicaltrials.gov/study/NCT07287917"}],"tags":["ctgov-ingest"],"related":[],"cancers":["melanoma","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["eflornithine","fulvestrant","capivasertib","pembrolizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT07287917","phase":"1/2","setting":"A Phase 1b/2 Trial Investigating the Safety and Efficacy of Oral AMXT 1501 and Oral DFMO in Combination With Standard of Care in Patients With Advanced Solid Tumors Who Progressed After Prior Therapies","sponsor":"Aminex Therapeutics, Inc.","enrolled":92,"outcomes":[]},"route":"/trials/nct07287917/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"drug":[{"id":"capivasertib","kind":"drug","name":"Capivasertib","route":"/drugs/capivasertib/"},{"id":"eflornithine","kind":"drug","name":"Eflornithine (DFMO)","route":"/drugs/eflornithine/"},{"id":"fulvestrant","kind":"drug","name":"Fulvestrant","route":"/drugs/fulvestrant/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}]}}