{"entity":{"id":"nct07289646","kind":"trial","name":"Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy","aka":["Pegasus 2"],"tldr":"A phase 3 trial in lung cancer, run by University Hospital, Brest, not yet recruiting.","summary":"Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy is a phase 3, randomised interventional study registered as NCT07289646 by University Hospital, Brest, with a registry enrolment figure of 418 participants, started 2026-01-15 and due to reach its primary completion in 2029-01-31. Interventions recorded: Conventional anatomical planning radiotherapy; Functional Lung avoidance planning. Conditions listed: Stereotactic Body Radiotherapy; 68Ga-MAA; Lung Cancer (Diagnosis). Primary outcome: To determine whether a functional planning guided by lung perfusion PET/CT imaging is superior to a conventional anatomical planning with regards to the occurrence of grade 2 or higher lung toxicity during the year following lung SBRT.. Lung eligibility wording from the registry: \"* Patients aged \\> 18 years planned to be treated in the radiotherapy department of the participating centers with SBRT for primary or secondary lung tumors will be eligible to participate into the study\". Sites: France. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07289646","url":"https://clinicaltrials.gov/study/NCT07289646"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["lung-cancer"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07289646","phase":"3","setting":"Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy","sponsor":"University Hospital, Brest","enrolled":418,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07289646/","neighbours":{"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}