{"entity":{"id":"nct07292298","kind":"trial","name":"Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by University of Colorado, Denver, now recruiting.","summary":"Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates is a phase 2, interventional study registered as NCT07292298 by University of Colorado, Denver, with a registry enrolment figure of 44 participants, started 2026-11 and due to reach its primary completion in 2030-11. Interventions recorded: High Rare Dose Rectal Brachytherapy Boost. Conditions listed: Rectal Adenocarcinoma; Rectal Cancer. Primary outcome: Organ preservation (no surgical requirement) of the rectum associated with complete clinical response. Colorectal eligibility wording from the registry: \"Patients with MMR-proficient low-mid rectal adenocarcinoma cT1-4 N0-2 M0 who underwent total neoadjuvant therapy who have not achieved complete response (i\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07292298","url":"https://clinicaltrials.gov/study/NCT07292298"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07292298","phase":"2","setting":"Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates","sponsor":"University of Colorado, Denver","enrolled":44,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07292298/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}