{"entity":{"id":"nct07314528","kind":"trial","name":"Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by St. James's Hospital, Ireland, not yet recruiting.","summary":"Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer is a phase 2, randomised interventional study registered as NCT07314528 by St. James's Hospital, Ireland, with a registry enrolment figure of 42 participants, started 2026-04 and due to reach its primary completion in 2028-09. Interventions recorded: GLP-1 receptor agonist; Total neoadjuvant therapy (TNT). Conditions listed: Rectal Cancer Patients; Obesity &Amp; Overweight; Locally Advanced Rectal Cancer (LARC); Total Neoadjuvant Therapy; GLP-1. Primary outcome: Weight Loss; Metabolic Profile of the Tissue; Inflammatory Mediators. Colorectal eligibility wording from the registry: \"* Histologically confirmed mismatch repair protein proficient adenocarcinoma of the rectum\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07314528","url":"https://clinicaltrials.gov/study/NCT07314528"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07314528","phase":"2","setting":"A Phase II Multi-institutional Randomized Trial Evaluating the Impact of GLP-1 Receptor Agonists in Combination With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer","sponsor":"St. James's Hospital, Ireland","enrolled":42,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07314528/","neighbours":{"cancer":[{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}