{"entity":{"id":"nct07321106","kind":"trial","name":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer","aka":[],"tldr":"A phase 1 trial of CBI-1214 run by Cartography Biosciences, now recruiting.","summary":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer is a phase 1 interventional study registered as NCT07321106 by Cartography Biosciences, with 80 participants planned, started 2026-01-15. Conditions recorded: Colorectal Cancer, Colorectal Cancer (CRC), Colorectal (Colon or Rectal) Cancer, CRC, Metastatic Colon Cancer, Colon Cancer and Advanced Colorectal Cancer. Interventions recorded: CBI-1214.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT07321106","url":"https://clinicaltrials.gov/study/NCT07321106"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["cbi-1214"],"companies":["cartography-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07321106","phase":"1","setting":"A Phase 1, First-in-human (FIH), Dose-Escalation and Dose-Optimization Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic Microsatellite Stable (MSS)/Microsatellite Instability Low (MSI-L) Colorectal Cancer","sponsor":"Cartography Biosciences","enrolled":80,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07321106/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"cbi-1214","kind":"drug","name":"CBI-1214","route":"/drugs/cbi-1214/"}],"company":[{"id":"cartography-biosciences","kind":"company","name":"Cartography Biosciences","route":"/companies/cartography-biosciences/"}]}}