{"entity":{"id":"nct07357220","kind":"trial","name":"A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases","aka":[],"tldr":"A phase 1/2 trial of ivonescimab in colorectal cancer, run by Akeso, not yet recruiting.","summary":"A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases is a phase 1/2, randomised interventional study registered as NCT07357220 by Akeso, with a registry enrolment figure of 72 participants, started 2026-03-02 and due to reach its primary completion in 2027-02-28. Interventions recorded: VG2025; AK112. Conditions listed: Colorectal Cancer With Hepatic Metastases. Primary outcome: Number of participants experiencing dose-limiting toxicities (DLTs); Number of participants with adverse events (AEs) and severity; Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed unresectable colorectal cancer with liver metastases; adenocarcinoma type\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07357220","url":"https://clinicaltrials.gov/study/NCT07357220"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["ivonescimab"],"companies":["akeso"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07357220","phase":"1/2","setting":"A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of AK112 in Combination With VG2025 in Patients With Advanced Colorectal Cancer With Liver Metastases","sponsor":"Akeso","enrolled":72,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07357220/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"ivonescimab","kind":"drug","name":"Ivonescimab","route":"/drugs/ivonescimab/"}],"company":[{"id":"akeso","kind":"company","name":"Akeso","route":"/companies/akeso/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}