{"entity":{"id":"nct07372625","kind":"trial","name":"A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.","aka":[],"tldr":"A phase 1 trial of Rezatapopt run by PMV Pharmaceuticals, Inc, now recruiting.","summary":"A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation. is a phase 1 interventional study registered as NCT07372625 by PMV Pharmaceuticals, Inc, with 14 participants planned, started 2026-02-04, primary completion expected 2027-03. Conditions recorded: TP53 Y220C Mutation, Advanced Solid Tumors. Interventions recorded: metformin hydrochloride 500 mg tablet, rosuvastatin 10 mg tablet, repaglinide 0.5 mg tablet, midazolam hydrochloride syrup, rezatapopt.","status":"recruiting","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT07372625","url":"https://clinicaltrials.gov/study/NCT07372625"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["rezatapopt"],"companies":["pmv-pharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07372625","phase":"1","setting":"A Phase 1, Open-label, 2-part, Drug-Drug Interaction Study to Evaluate the Effects of Multiple Oral Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.","sponsor":"PMV Pharmaceuticals, Inc","enrolled":14,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07372625/","neighbours":{"drug":[{"id":"rezatapopt","kind":"drug","name":"Rezatapopt","route":"/drugs/rezatapopt/"}],"company":[{"id":"pmv-pharma","kind":"company","name":"PMV Pharma","route":"/companies/pmv-pharma/"}]}}